CHRONIC TOXICITY EXTRACTION OF AFRICAN MESQUITE TREE PART EXTRACT IN RAT
- Project Research
- 1-5 Chapters
- Abstract : Available
- Table of Content: Available
- Reference Style: Available
- Recommended for : Student Researchers
- NGN 3000
ABSTRACT
This study investigated the chronic toxicity of African Mesquite tree (Prosopis africana) extracts in Wistar rats, focusing on biochemical, hematological, and histopathological effects. The extracts were administered at doses of 100 mg/kg, 300 mg/kg, and 600 mg/kg over a 90-day period. Biochemical analyses indicated significant dose-dependent increases in liver function markers (ALT, AST, ALP, and bilirubin) and kidney function markers (urea and creatinine), suggesting hepatocellular injury and nephrotoxicity. Hematological findings showed reductions in hemoglobin, red blood cells, platelets, and hematocrit levels at higher doses, indicating potential hematotoxic effects. Histopathological examinations corroborated these results, revealing extensive necrosis and fibrosis in liver and kidney tissues, as well as damage in heart, lungs, and spleen at the highest dose. Comparisons with control groups highlighted significant deviations in treated groups, with statistical analysis confirming the significance of these changes (p<0.05). The findings underscore the potential risks associated with high doses of African Mesquite tree extracts, necessitating cautious use in traditional medicine. This study contributes to the growing body of evidence on the safety profiles of herbal remedies and highlights the need for stringent regulation and monitoring of their use. Future research should focus on long-term toxicity, identification of specific bioactive compounds, and clinical studies in humans to establish safe dosage guidelines. Public awareness campaigns, healthcare provider training, and robust regulatory frameworks are recommended to ensure the safe use of herbal medicines.
Related Project Materials
INVESTIGATION OF OCCUPATIONAL SAFETY AND HEALTH(OSH) COMPLIANCE LEVEL IN ADDRESSING COVID 19 PANDEMIC IN THE INDUSTRIAL SECTOR
BACKGROUND OF THE STUDY
In December 2019, the global population will be awoken to an outbreak of a dise...
ACCEPTANCE AND UTILISATION OF FAMILY PLANNING SERVICES AMONGST SECONDARY SCHOOL STUDENTS
1.1 Background to Study
Family planning is widely acknowledged as an important intervention towards achieving Millennium Development Goal...
THE IMPACT OF MOTIVATION ON STAFF PERFORMANCE IN THE BANKING INDUSTRY IN NIGERIA
ABSTRACT
This study looked into the impact of motivation on staff performance in the banking industry i...
EFFECT OF STUDY HABITS ON THE ACADEMIC PERFORMANCE OF GEOGRAPHY STUDENTS IN SELECTED SECONDARY SCHOOL
ABSTRACT
In educational situation, success is measured by academic performance or how well a student me...
FEMALE CIVIL SERVANTS’ PERCEPTION AND PATTERN OF USE OF NEW MEDIA IN SOUTH EAST NIGERIA
Background of the Study
Historically the Internet emerged in the early 1970’s as a product of research which aimed to connect...
IMPACT OF STRATEGIC PLANNING ON BUSINESS GROWTH AND PROFITABILITY. A STUDY OF DANA PHARMACEUTICAL COMPANY LIMITED MINNA
ABSTRACT
The study focused on Impact of strategic planning on business growth and profitability. A stud...
NEWSPAPER READERSHIP PATTERNS IN NIGERIA
ABSTRACT
The study examined newspapers readership in Osun State with a careful look at the patterns and challenges facing readers particu...
REVENUE GENERATION, UTILIZATION AND GRASSROOT TRANSFORMATION IN NIGERIA
ABSTRACT
Revenue generation in the public sector is very important because of demand for economic devel...
THE EFFECT OF POVERTY AND ACCESS TO HEALTH-CARE
ABSTRACT
People in poor countries tend to have less access to health services than those in better-off countries, and wi...
THE RELATIONSHIP BETWEEN E-NAIRA AND E-BANKING
Background of the study
The notion of electronic banking was born as a result of technological improvem...
