ABSTRACT
This study investigated the chronic toxicity of African Mesquite tree (Prosopis africana) extracts in Wistar rats, focusing on biochemical, hematological, and histopathological effects. The extracts were administered at doses of 100 mg/kg, 300 mg/kg, and 600 mg/kg over a 90-day period. Biochemical analyses indicated significant dose-dependent increases in liver function markers (ALT, AST, ALP, and bilirubin) and kidney function markers (urea and creatinine), suggesting hepatocellular injury and nephrotoxicity. Hematological findings showed reductions in hemoglobin, red blood cells, platelets, and hematocrit levels at higher doses, indicating potential hematotoxic effects. Histopathological examinations corroborated these results, revealing extensive necrosis and fibrosis in liver and kidney tissues, as well as damage in heart, lungs, and spleen at the highest dose. Comparisons with control groups highlighted significant deviations in treated groups, with statistical analysis confirming the significance of these changes (p<0.05). The findings underscore the potential risks associated with high doses of African Mesquite tree extracts, necessitating cautious use in traditional medicine. This study contributes to the growing body of evidence on the safety profiles of herbal remedies and highlights the need for stringent regulation and monitoring of their use. Future research should focus on long-term toxicity, identification of specific bioactive compounds, and clinical studies in humans to establish safe dosage guidelines. Public awareness campaigns, healthcare provider training, and robust regulatory frameworks are recommended to ensure the safe use of herbal medicines.
ABSTRACT
The need for keeping prompt and accurate record of transaction in the government services of the receipt and di...
ABSTRACT
The study examined the impact of family background on the academic performance on primary scho...
Background to the study
The Constitution of Nigeria clearly ensures the separation of powers as an underlining principle...
ABSTARCT
The main focus of this study is to assess impact of the internet on postgraduate researc...
ABSTRACT
Safety of food is a basic requirement of food quality. A total of 25 street food samples (Jollof rice, egwusi soup, ugu, water l...
ABSTRACT
The belief in reincarnation has affected some Christians at many levels ranging from belief, experience and ritual relation to t...
Abstract: This study investigates the impact of change management on project success, aiming to: 1) identify...
ABSTRACT
Electronic banking is a subject receiving great attention in the banking industry and the regulation agencies. It is a driving f...
ABSTRACT
This study was conducted on the Assessment of Conflict Control Mechanisms in Administration of Junior Secondary Schools in Feder...
Background of the study
Banks are a vital part of every economy. It is the driving force behind society...